Conventional diffusion-weighted MR imaging techniques provide limited specificity in disentangling disease-related microstructural alterations involving changes in both axonal density and myelination. By simultaneously probing multiple diffusion regimens, multi-shell diffusion MRI is capable of increasing specificity to different tissue sub-compartments and hence separate contributions to changes in diffusion-weighted signal attenuation.

Selected publications:

1) Granberg T, Fan Q, Treaba CA, Ouellette R, Herranz E, Mangeat G, Louapre C, Cohen-Adad J, Klawiter EC, Sloane J, Mainero C. In vivo characterization of cortical and white matter neuroaxonal pathology in early multiple sclerosis. Brain, 2017 Nov 1;140(11):2912-2926. doi: 10.1093/brain/awx247. PMID: 29053798.

2) De Santis S, Granberg T, Ouellette R, Treaba CA, Qiuyun Fan, Herranz E, *Mainero C, *Toschi N. Early axonal damage in normal appearing white matter in multiple sclerosis: Novel insights from multi-shell diffusion MRI. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:3024-3027. doi: 10.1109/EMBC.2017.8037494. PMID: 29060535.

3) Mangeat G, Badji A, Ouellette R, Treaba CA, Herranz E, Granberg T, Louapre C, Stikov N, Sloane JA, Bellec P, Mainero C, Cohen-Adad J. Changes in structural network are associated with cortical demyelination in early multiple sclerosis. Hum Brain Mapp. 2018 May;39(5):2133-2146. doi: 10.1002/hbm.23993.